Sunday's clash between Manchester United and Chelsea is likely to be a titanic battle, but it's the Blues who enter the fixture a cut about their rival.
Tottenham will be hoping to avoid a European hangover when they play host to struggling Newcastle in the Premier League on Sunday.
Southampton will be targeting more of the same when Stoke City make the trip to St Mary's Stadium on Saturday for a Premier League clash.
Swansea will be looking to snap a five-game winless run when they host Leicester for a Premier League encounter on Saturday.
Chiefs will be looking to maintain their dominance over Platinum Stars when the two sides lock horns in the Telkom Knockout on Sunday.
Liverpool manager Brendan Rodgers is expected to ring the changes for Saturday's Premier League clash with Hull City at Anfield.
West Brom will be hoping to put more daylight between themselves and the relegation zone when they host Crystal Palace on Saturday.
Pirates will be looking to bounce back to winning ways when they face Ajax Cape Town in the Telkom Knockout quarter-finals on Saturday.
Bidvest Wits switch their focus to the Telkom Knockout quarter-finals with SuperSport United paying them a visit on Saturday.
West Ham United will be looking to end their poor run of results against Manchester City when the two sides face off at Upton Park on Saturday.
Arsenal will be hoping to kick start their Premier League campaign when they travel to the Stadium of Light to face Sunderland on Saturday.
Teko Modise and Alje Schut are injury doubts for Sundowns ahead of their Telkom Knockout quarter-final against AmaZulu on Saturday.
Kaizer Chiefs will be looking to continue their incredible winning run when they welcome Moroka Swallows to the FNB Stadium on Wednesday.
Tottenham continue their campaign in the Europa League when they take on Greek outfit Asteras Tripolis at White Hart Lane on Thursday.
- Lille v Everton
- Uni of Pretoria v Bloem Celtic
- Bidvest Wits v Polokwane City
- Ajax CT v Platinum Stars
- SuperSport v Maritzburg United
- Anderlecht v Arsenal
- Liverpool v Real Madrid
- Black Aces v Pirates
- Chelsea v NK Maribor
- CSKA Moscow v Man City
- West Brom v Manchester United
- Maritzburg v Platinum Stars
- AmaZulu v Chippa United
- Uni of Pretoria v SuperSport
- Arsenal v Hull City
- Stoke City v Swansea
- Crystal Palace v Chelsea
- Sundowns v Bidvest Wits
- Bloem Celtic v Polokwane City
- Newcastle v Leicester
- Swallows v Black Aces
- Ajax CT v Kaizer Chiefs
- Everton v Aston Villa
- Manchester City v Tottenham
- South Africa v Congo