University of Pretoria will be desperate to breath new life into their top-eight hopes on Tuesday, but face a Moroka Swallows side battling for their Premiership survival.
Virgil Vries will continue as captain in place of injured Ashley Hartog when Maritzburg host Ajax Cape Town at Harry Gwala Stadium on Tuesday.
West Bromwich Albion will be targeting back-to-back victories when Champions League hopefuls Liverpool visit the Hawthorns on Saturday afternoon.
Stoke City will be targeting more of the same when stragglers Sunderland make the trip to the Britannia Stadium on Saturday afternoon.
Queen Park Rangers will be aiming to improve their survival prospects when they welcome a struggling West Ham United to Loftus Road on Saturday.
Crystal Palace will be eyeing a return to winning ways when relegation-threatened Hull City visit Selhurst Park on Saturday afternoon.
Burnley have replaced Leicester City at the bottom of the Premier League table, but will want to change that when they welcome the Foxes to Turf Moor on Saturday.
Ajax Cape Town and SuperSport United are both expected to be at full strength for Saturday's Nedbank Cup semi-final clash.
Chelsea will have the chance to all but secure the Premier League title when they travel to the Emirates Stadium to face Arsenal in a battle of the top two on Sunday.
Newcastle will have to get over their losing streak and the protests against club owner Mike Ashley in time for their Premier League encounter against Swansea on Saturday.
Mamelodi Sundowns have one last chance to capture silverware this season and will be out to secure a Nedbank Cup final berth when they face Vasco da Gama on Sunday.
Mauricio Pochettino will be looking for a positive result to aid Tottenham's European ambitions when they take on Southampton at St Mary's Stadium on Saturday.
Manchester United will be looking to secure their place in the top three when they travel to Goodison Park to face Everton on Sunday.
Manchester City will be looking to reclaim second place in the Premier League when they welcome Aston Villa to the Etihad Stadium on Saturday evening.
- Pirates v Pretoria University
- Kaizer Chiefs v Polokwane City
- Real Madrid v Atletico Madrid
- Sundowns v Plat Stars
- Monaco v Juventus
- FS Stars v Ajax CT
- Bayern v Porto
- Barcelona v PSG
- Polokwane v FS Stars
- Leicester v Swansea
- Stoke v Southampton
- Crystal Palace v West Brom
- SuperSport United v Swallows
- Man City v West Ham
- Aston Villa v Liverpool
- Bidvest Wits v Chippa United
- Reading v Arsenal
- Everton v Burnley
- Newcastle v Tottenham
- Chelsea v Manchester United
- Bloem Celtic v Maritzburg
- Ajax CT v Pretoria University
- PSG v Barcelona
- FC Porto v Bayern Munich
- Black Aces v Maritzburg Utd