Tottenham will be looking to exact some revenge on Liverpool when they come calling at White Hart Lane on Sunday.
Swansea hope to build on their early momentum when they host West Brom in an important Premier League fixture on Saturday.
Sunderland currently have a tiger by the tail and are unlikely to let it go when they play Queens Park Rangers in the Premier League on Saturday.
It will be a battle between the league's inconsistent teams when Black Aces and University of Pretoria clash at the Mbombela Stadium on Saturday.
Orlando Pirates will be targeting back-to-back Premiership wins when they travel to the Peter Mokaba Stadium to face Polokwane City on Saturday.
Even a squad as depleted as Newcastle will fancy their prospects of collecting maximum points against Crystal Palace at St James' Park on Saturday.
Former Chelsea strikers Romelu Lukaku and Samuel Eto'o will be out to prove a point as their Everton side host the Blues on Saturday.
Glenn Verbauwhede and Andrea Fileccia are unlikely to be registered in time to feature for Free State Stars against Maritzburg United on Saturday.
Mamelodi Sundowns are expected to be without captain Alje Schut when they host AmaZulu in their Premiership clash at Loftus Stadium on Sunday.
Southampton travel to West Ham on Saturday searching for their first league victory under new manager Ronald Koeman.
Early pacesetters Kaizer Chiefs will be looking to keep their 100 percent record intact when they host SuperSport United at the FNB Stadium on Saturday.
Man City will be looking to maintain their 100 percent start to the new season when they welcome Stoke to the Etihad Stadium on Saturday.
Manchester United will go in search of their first win of the new season when they travel to Burnley for Saturday's early kick-off.
Platinum Stars and Bloemfontein Celtic will both be looking for much more consistency when they lock horns Sunday afternoon.
- Chippa v Ajax Cape Town
- Wits v Moroka Swallows
- Tottenham v AEL Limassol
- Hull City v Lokeren
- SuperSport Utd v Black Aces
- Aston Villa v Leyton Orient
- Burton v QPR
- Stoke City v Portsmouth
- Sundowns v Pirates
- Birmingham v Sunderland
- Platinum Stars v Chiefs
- AmaZulu v Bloemfontein Celtic
- Pretoria Uni v Free State Stars
- Arsenal v Besiktas
- Swansea City v Rotherham
- Ajax Cape Town v Wits
- Walsall vs Crystal Palace
- Leicester City v Shrewsbury
- Swallows v Polokwane City
- West Brom v Oxford United
- West Ham v Sheffield United
- Millwall v Southampton
- Maritzburg Utd v Chippa Utd
- Gillingham v Newcastle
- MK Dons v Manchester United