Southampton will be hoping Manchester City will be distracted by next week's Champions League game when the sides meet at St Mary's in the Premier League on Sunday.
In-form Dortmund will be full of confidence for their Bundesliga match against an out-of-sorts Wolfsburg outfit at Signal Iduna Park on Saturday afternoon.
Bayern could clinch a record fourth consecutive Bundesliga crown with a win over Monchengladbach at the Allianz Arena on Saturday afternoon.
Relegated Aston Villa will be looking to avoid an 11th straight Premier League defeat when they lock horns with Watford at Vicarage Road on Saturday.
Swansea will be aiming to confirm their league safety when Europa League semi-finalists Liverpool visit the Liberty Stadium in Sunday's early Premier League kick-off.
Polokwane City will be hoping to secure their Premiership survival on Saturday when they host an out of form Mpumalanga Black Aces side at the Peter Mokaba Stadium.
Arsenal will look to get their Champions League challenge back on track when they welcome Norwich to the Emirates Stadium on Saturday in the late kick-off.
Everton striker Romelo Lukaku will be looking to regain his form, having failed to score in his last six league games, when his side welcomes AFC Bournemouth at Goodison Park on Saturday.
Jomo Cosmos will host University of Pretoria in what will be a classic relegation do-or-die dogfight at Olen Park on Sunday.
West Brom will be looking to end their six-match winless run in all competitions when they host West Ham United at the Hawthorns for their Premier League clash on Saturday.
Mamelodi Sundowns will look to restore their seven-point lead atop the Premiership table with a positive result against Kaizer Chiefs on Saturday.
Newcastle United's players will be looking to get one over their former manager, Alan Pardew, when they welcome Crystal Palace to St James' Park on Saturday.
Stoke City will be looking to get back to winning ways when they host struggling Sunderland at the Britannia Stadium on Saturday.
Leicester City can clinch the Premier League title on Sunday with victory over Manchester United at Old Trafford.
- Golden Arrows v Free State Stars
- Atletico Madrid v Bayern Munich
- Maritzburg United v SuperSport United
- Villarreal v Liverpool
- Shakhtar Donetsk v Sevilla
- Manchester City v Real Madrid
- Tottenham v West Brom
- Ajax Cape Town v Mamelodi Sundowns
- Chippa United v Platinum Stars
- Orlando Pirates v Polokwane City
- Black Aces v Golden Arrows
- University of Pretoria v Kazier Chiefs
- Jomo Cosmos v Bloem Celtic
- SuperSport Utd v Bidvest Wits
- Sunderland v Arsenal
- FS Stars v Maritzburg Utd
- Bournemouth v Chelsea
- Crystal Palace v Watford
- Aston Villa v Southampton
- Everton v Manchester United
- Mamelodi Sundowns v Orlando Pirates
- Polokwane City v Baroka FC
- Liverpool v Newcastle
- Manchester City v Stoke City
- Free State Stars v Bidvest Wits