England's two most in-form strikers go head to head as Charlie Austin and Harry Kane prepare to do battle when Tottenham take on QPR at Loftus Road on Saturday.
Bradford manager Phil Parkinson has told his players they will have to play better than they have all season to beat Reading in their FA Cup sixth round match on Saturday.
Aston Villa will have a shot at redemption when they play against West Bromwich Albion in the quarter-final of the FA Cup on Saturday.
Platinum Stars and Moroka Swallows will both be desperate for points when the relegation-threatened clubs meet in the Premiership at Royal Bafokeng Stadium on Sunday.
Both SuperSport United and Ajax Cape Town will be looking to bounce back from defeats when the sides lock horns at the Peter Mokaba Stadium on Saturday.
The biggest match on the South African top-flight calendar takes place on Saturday as Kaizer Chiefs and Orlando Pirates lock horns in the 155th installment of the Soweto Derby.
Black Aces have been handed a triple boost ahead of their Premiership clash against AmaZulu on Saturday with Aubrey Ngoma, Doctor Mampuru and Clifford Ngobeni all declared fit.
Siyabonga Ngubane and Mpho Maruping will both miss out when University of Pretoria welcome Maritzburg United to the Tuks Stadium on Sunday.
Bidvest Wits will be hoping to keep the pressure on pace-setters Kaizer Chiefs by taking all three points from their clash with Bloemfontein Celtic on Friday night.
Stoke will look to strengthen their place in the top-10 when they welcome struggling Everton to the Britannia Stadium on Wednesday night.
Manchester United will attempt to cement their place in the top-four when they take on Newcastle at St James' Park on Wednesday night.
Kaizer Chiefs will be targeting a return to winning ways in the Premiership when Ajax Cape Town make the trip to the FNB Stadium on Wednesday night.
Chippa United are hoping to climb the Premiership table when they welcome Polokwane City to the Nelson Mandela Bay Stadium on Wednesday.
Tottenham will be desperate to get a result against Swansea when the teams meet at White Hart Lane in the Premier League on Wednesday.
- QPR v Arsenal
- West Ham v Chelsea
- Liverpool v Burnley
- FS Stars v Orlando Pirates
- Manchester City v Leicester
- Southampton v Crystal Palace
- Aston Villa v West Brom
- Hull v Sunderland
- Sundowns v Bidvest Wits
- West Brom v Southampton
- Newcastle v Aston Villa
- Bloem Celtic v Platinum Stars
- Stoke City v Hull City
- Royal Leopards vs Bidvest Wits
- West Ham v Crystal Palace
- Man Utd v Sunderland
- Chelsea v Tottenham
- Township Rollers v Kaizer Chiefs
- Arsenal v Everton
- Maritzburg v Free State Stars
- Liverpool v Manchester City
- Burnley v Swansea City
- Pretoria Uni v MP Black Aces
- Orlando Pirates v Polokwane
- SuperSport United v AmaZulu