Moroka Swallows will be looking to maintain their strong start to the new season when they face Bidvest Wits in Johannesburg on Friday.
Tottenham host AEL Limassol in the Europa League play-offs on Thursday knowing that a clean sheet will see them through to the group stages.
Hull City will be looking to overturn a one-goal deficit when they host Lokeren in their Europa League play-off decider at the KC Stadium.
Mpumalanga Black Aces will have a rare opportunity to collect three Premiership points when they play against SuperSport United on Wednesday night.
Aston Villa welcome Leyton Orient to Villa Park on Wednesday evening as overwhelming favourites to progress from the second round of the League Cup.
Burton Albion will take a step into the unknown when they lock horns with Queens Park Rangers in their first ever competitive encounter on Wednesday.
Mark Hughes is expected to ring the changes for Wednesday night's Capital One Cup second-round clash with Portsmouth.
Fireworks are expected when Orlando Pirates visit league champions Mamelodi Sundowns for a Premiership encounter on Wednesday.
Sunderland will be hoping to start their Capital One Cup campaign with a win when they travel to Birmingham City on Wednesday night.
Early pacesetters Kaizer Chiefs and Platinum Stars will face off for the third time this month when they clash in a league match on Wednesday.
AmaZulu have Ayanda Dlamini and Bornwell Mwape both available for Wednesday's Premiership clash against Bloemfontein Celtic.
University of Pretoria will welcome Free State Stars to the Tuks Stadium on Wednesday, with both sides looking for more consistency.
Arsenal will be without two key figures when they host Besiktas in the second leg of their Champions League play-off on Wednesday.
Swansea manager Garry Monk is expected to rest several first-team regulars for Tuesday night's Capital One Cup clash with Rotherham.
- Ajax Cape Town v Wits
- Walsall vs Crystal Palace
- Leicester City v Shrewsbury
- Swallows v Polokwane City
- West Brom v Oxford United
- West Ham v Sheffield United
- Millwall v Southampton
- Maritzburg Utd v Chippa Utd
- Gillingham v Newcastle
- MK Dons v Manchester United
- Manchester City v Liverpool
- Sunderland v Man Utd
- Tottenham v QPR
- Hull City v Stoke
- Crystal Palace v West Ham
- Southampton v West Brom
- Chiefs v Platinum Stars
- Chelsea v Leicester City
- Pirates v Bidvest Wits
- Swansea v Burnley
- Aston Villa v Newcastle
- Everton v Arsenal
- AEL Limasson v Tottenham
- Lokeren v Hull City
- Platinum Stars v Black Aces