Liverpool will be looking to bounce back from a debilitating loss to Hull City when they host Norwich City at Anfield on Wednesday evening.
Southampton will be looking to bounce back from two successive league defeats when they welcome Aston Villa to St Mary's on Wednesday evening.
Alan Pardew's in-form Newcastle United will travel to the Liberty Stadium on Wednesday to take on Michael Laudrup's stuttering Swansea City.
It will be interesting to see how Moroka Swallows line up when they host Bidvest Wits at the Dobsonville Stadium on Wednesday night.
Struggling Fulham will welcome another embattled London club to Craven Cottage when Tottenham travel to the capital's east on Wednesday.
David Moyes faces his former club for the first time when Everton travel to Old Trafford for a clash with Manchester United on Wednesday.
New coach Ernst Middendorp begins his overhaul of Bloemfontein Celtic against Lamontville Golden Arrows on Wednesday night.
Mpumalanga Black Aces welcome leaders Mamelodi Sundowns to the Mbombela Stadium for a crucial league match on Wednesday night.
West Bromwich Albion host Manchester City on Wednesday with the visitors looking for a rare away win in this season's Premier League.
Chelsea will be without the Brazilian duo of David Luiz and Oscar when they travel to the Stadium of Light to face Sunderland on Wednesday.
Stoke City and Cardiff City will both look to put heavy defeats behind them when they face off at the Britannia Stadium on Wednesday.
University of Pretoria are set to welcome a dented Free State Stars to the Tuks Stadium for a league engagement on Wednesday night.
Premier League leaders Arsenal will look to make it three wins on the bounce when they welcome Hull City to the Emirates on Wednesday.
Tony Pulis will be targeting his first win as Crystal Palace manager when West Ham United visit Selhurst Park on Tuesday evening.
- Athletic Bilbao v Barcelona
- Man City v Swansea
- Hull City v Liverpool
- West Ham v Fulham
- Norwich v Crystal Palace
- Aston Villa v Sunderland
- Everton v Stoke City
- Tottenham v Man United
- Chelsea v Southampton
- Newcastle v West Brom
- Cardiff v Arsenal
- Real Madrid v Valladolid
- Sundowns v Swallows
- Orlando Pirates v Bloem Celtic
- FS Stars v Kaizer Chiefs
- Golden Arrows v Platinum Stars
- Pretoria Uni v AmaZulu
- Real Madrid v Galatasaray
- Chiefs v Polokwane City
- Man City v Viktoria Plzen
- Bayer Leverkusen v Man Utd
- Maritzburg v Orlando Pirates
- AmaZulu v Platinum Stars
- SuperSport United v Ajax
- Ajax v Barcelona