Liverpool will be hoping for some cup cheer when they take on AFC Bournemouth in the Capital One Cup quarter-finals on Wednesday night.
Bloemfontein Celtic coach Clinton Larsen will be under pressure to produce immediate results when his club plays against Mpumalanga Black Aces at the Mbombela Stadium.
Chippa United will be out to avoid a third successive league defeat when they take on Platinum Stars at the Royal Bafokeng Stadium on Wednesday night.
Moroka Swallows are up for a challenging evening on Wednesday when they take on an Orlando Pirates side fresh from a 4-0 win over Ajax Cape Town.
Wits will be hoping to return to winning ways in the Premiership and cut the lead at the top of the standings when they host SuperSport on Wednesday.
Chelsea manager Jose Mourinho is expected to ring the changes for Tuesday's Capital One Cup semi-final clash with Derby County at Pride Park Stadium.
Ronald Koeman's Southampton side take on Sheffield United in the quarter-finals of the Capital One Cup on Tuesday.
Kaizer Chiefs have an opportunity to stretch their lead at the top of the Premiership standings when they host Free State Stars at the Peter Mokaba Stadium on Tuesday.
Polokwane City will be looking to extend their unbeaten Premiership run and climb into the top eight when they host University of Pretoria on Tuesday.
Maritzburg's on-loan pair Ntuthuko Mabaso and Kwanda Mngonyama are both eligible to face parent club Mamelodi Sundowns at the Harry Gwala Stadium on Tuesday.
Travis Graham and Bantu Mzwakali are available again for Ajax Cape Town ahead of their Premiership clash against AmaZulu on Tuesday.
Everton will be looking to end their winless run when stragglers Queens Park Rangers make the trip to Goodison Park on Monday night.
Sunderland entertain an in-form West Ham side on Saturday in desperate need of a win to avoid a potential relegation scrap.
Leicester City can expect a stern test of their Premier League credentials when Manchester City visit the King Power Stadium on Saturday.
- Man Utd v Liverpool
- Swansea v Tottenham
- Black Aces v Free State Stars
- Chelsea v Hull City
- Pretoria Uni v Sundowns
- Burnley v Southampton
- SuperSport v Polokwane City
- Arsenal v Newcastle
- Crystal Palace v Stoke City
- Bloem Celtic v Moroka Swallows
- West Brom v Aston Villa
- Kaizer Chiefs v Chippa United
- Platinum Stars v Bidvest Wits
- Maritzburg United v AmaZulu
- Besiktas v Tottenham
- Everton v Krasnodar
- Chelsea v Sporting CP
- Orlando Pirates v Sundowns
- Bidvest Wits v Ajax Cape Town
- Roma v Manchester City
- Kaizer Chiefs v Platinum Stars
- Liverpool v FC Basel
- Galatasaray v Arsenal
- Southampton v Man Utd
- Hull City v West Brom