Ajax Cape Town will be hoping to break their bogey away to Free State Stars when they take on Ea Lla Koto in Bethlehem on Saturday afternoon.
Hull City will be keen to prevent Sunderland from another cup semi-final when the two sides square up in the FA Cup quarter-finals on Sunday.
Orlando Pirates interim boss Eric Tinkler will be hoping to end his tenure on a high when his team face the University of Pretoria on Saturday.
Chelsea hope to consolidate their position at the top of the Premier League standings when they host Tottenham Hotspur.
Cardiff City hope to return to winning ways when they host Fulham in a Premier League fixture this Saturday.
Manchester United will look to build on their victory last time out when they travel to the Hawthorns to face West Brom on Saturday.
Norwich will be hoping to bounce back from a 4-1 defeat to Aston Villa when they welcome Stoke City to Carrow Road on Saturday.
Real Madrid have a glorious opportunity to entrench their status as outright favourites for the La Liga title when they host Levante.
Real Valladolid and Barcelona will be desperate for a win when they compete in a Spanish La Liga fixture at the Nuevo Jose Zorrilla on Saturday.
Manchester City will be out for revenge when they face Wigan in an FA Cup quarter-final on Sunday, having lost to the Latics in the final last May.
Bidvest Wits will be searching out a fourth consecutive win in the league when they face Polokwane City in the Limpopo this weekend.
Kaizer Chiefs know that they cannot afford any complacency in their second leg first round CAF Champions League away to Liga Desportiva Muçulmana.
Arsenal will look to restore a bit of confidence when they host Everton in an FA Cup quarter-final clash at the Emirates on Saturday.
Moroka Swallows, yet to win a league game in 2014, square up to an in-form Bloemfontein Celtic side at the Dobsonville Stadium on Sunday.
- AFC Leopards v SuperSport
- Black Aces v Platinum Stars
- Mexico v Nigeria
- Montenegro v Ghana
- Cyprus v Northern Ireland
- Zambia v Uganda
- Wales v Iceland
- England v Denmark
- Republic of Ireland v Serbia
- Barcelona v Almeria
- Aston Villa v Norwich
- Atletico Madrid v Real Madrid
- Swansea v Crystal Palace
- Pirates v Free State Stars
- Tottenham v Cardiff
- Wits v Sundowns
- Southampton v Liverpool
- Bloem Celtic v Black Aces
- Manchester City v Sunderland
- Chiefs v Liga Desportiva
- Arrows v Pretoria University
- Everton v West Ham
- Stoke City vs Arsenal
- Fulham vs Chelsea
- SuperSport v AFC Leopards