Scotland have a good opportunity to gain an advantage in Euro 2016 qualifying Group D when they welcome Gibraltar to Hampden Park in Glasgow on Sunday.
South Africa will continue their rebuilding process on Sunday afternoon when they host Nigeria in a friendly international at the Mbombela Stadium.
Wales will be looking to go top of Group B when they travel to the Sami Ofer Stadium in Haifa to face Israel in a crunch 2016 European Championships qualifier on Saturday.
England will be looking to make it five wins from five in their Euro 2016 qualifying campaign when they host Lithuania at Wembley on Friday evening.
Liverpool will be determined to keep their Champions League aspirations alive when they take on bitter rivals Manchester United at Anfield on Sunday.
Scotland will be aiming to make a winning start to the international break when they lock horns with Northern Ireland at Hampden Park on Wednesday.
South Africa will contest their first match since crashing out of AFCON 2015 when they travel to the Somhlolo National Stadium to face Swaziland on Wednesday.
Queens Park Rangers welcome Everton to Loftus Road on Saturday desperate to put an end to their dismal losing run in the Premier League.
West Ham United will be hoping to end a worrying run of results when they welcome stragglers Sunderland to Upton Park on Saturday evening.
Mamelodi Sundowns will be aiming to exact some revenge on Platinum Stars when the two sides meet in Sunday's Nedbank Cup last-16 clash.
Hull City will be looking to put some more daylight between themselves and the relegation zone when they host Chelsea at the KC Stadium on Sunday.
Regular cup rivals SuperSport United and Orlando Pirates will slug it out one more time when they meet in the Nedbank Cup last 16 on Saturday night.
Newcastle head coach John Carver will only have 13 fit senior players to choose from his side take on an in-form Arsenal at St James' Park on Saturday.
Black Aces will be hoping to put some poor league form out of their minds when they take on Jomo Cosmos at the Mbombela Stadium on Saturday.
- Kaizer Chiefs v Black Leopards
- Aston Villa v Swansea
- Manchester City v West Brom
- Ajax CT v Bloem Celtic
- Dynamo Kyiv v Everton
- Barcelona v Manchester City
- Orlando Pirates v Black Aces
- Sundowns v Chippa Utd
- Moroka Swallows v Kaizer Chiefs
- Monaco v Arsenal
- Bidvest Wits v Pretoria Uni
- Swansea v Liverpool
- Crystal Palace v QPR
- Man Utd v Tottenham
- SuperSport United v Tuks
- West Brom v Stoke
- Polokwane City v Bloem Celtic
- Burnley v Man City
- Arsenal v West Ham
- Sundowns v TP Mazembe
- Sunderland v Aston Villa
- Leicester v Hull
- Chelsea v Southampton
- Everton v Newcastle
- Chiefs v Raja Casablanca