Bidvest Wits will be determined to keep their title hopes alive by securing maximum points against University of Pretoria at the Tuks Stadium on Sunday.
Chippa United will go in search of a first Premiership win in four when they host SuperSport United at the Nelson Mandela Bay Stadium on Sunday.
Newcastle United will be hoping for home comforts when Sunderland make the trip to St James' Park on Sunday afternoon.
Hull City will be looking to climb out of the Premier League relegation zone when they host Swansea City at the KC Stadium on Saturday.
Arsenal will be looking to take advantage of a despondent Liverpool and climb into the Premier League's top four when they travel to Anfield on Sunday.
Two clubs with new coaches at the helm, Orlando Pirates and Bloemfontein Celtic, go head to head at the Orlando Stadium on Saturday night.
Manchester United will be looking to make it seven wins on the trot when they travel to Villa Park to face Aston Villa on Saturday.
Free State Stars take on Platinum Stars at Goble Park on Saturday with the hope of pulling themselves out of the Premiership relegation zone.
Tottenham Hotspur and Burnley will both be looking to pick up their second consecutive wins when they collide at White Hart Lane on Saturday.
Manchester City will have the chance to go level at the top of the Premier League standings when they welcome Crystal Palace to the Etihad Stadium on Saturday.
Ajax Cape Town will be desperate to end a five-match winless streak as they head up to Pretoria to take on Mamelodi Sundowns on Saturday.
Modiri Marumo is a major injury concern for Polokwane City ahead of their Premiership clash against Maritzburg United on Saturday night.
Southampton will be looking to end a dismal run of form when Everton make the trip to St Mary's on Saturday.
Kaizer Chiefs will be looking to cement their position as the best team in the league by closing out the year with a win over Black Aces.
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- Heavy Costa for Stoke against Chelsea
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- Black Cats to edge commitment over Magpies
- Go for goals as City face Palace
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- Bournemouth v Liverpool
- Black Aces v Bloem Celtic
- Swallows v Pirates
- Bidvest Wits v SuperSport
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- Kaizer Chiefs v Free State Stars
- Wenger admits Ox injury concern
- Sunderland v West Ham
- Leicester v Man City
- Man Utd v Liverpool
- Black Aces v Free State Stars
- Orlando Pirates v Ajax CT
- Chelsea v Hull City
- Pretoria Uni v Sundowns
- Burnley v Southampton
- Arsenal v Newcastle
- Crystal Palace v Stoke City