West Brom will attempt to do the season double over Tottenham when the two teams lock horns at the Hawthorns on Saturday.
Chelsea will have the chance to stretch further ahead at the Premier League summit when Manchester City visit Stamford Bridge on Saturday.
Queens Park Rangers fans expect to see at least three of their first-team players return to the fray when the club plays against Stoke City at the Britannia on Saturday.
Ivory Coast will see Sunday's quarter-final against Algeria in Malabo as an opportunity to exact some revenge in what is the pick of this weekend's Africa Cup of Nations action.
Arsenal will be looking to climb into the top four of the Premier League when they host Aston Villa at the Emirates Stadium on Sunday.
Relegation-threatened sides Sunderland and Burnley go head to head in a Premier League encounter at the Stadium of Light on Saturday.
Crystal Palace are level on points with Everton as the sides prepare to meet in a Premier League fixture at Selhurst Park on Saturday.
Manchester United will be out for revenge when they welcome Leicester City to Old Trafford for their Premier League encounter on Saturday.
Liverpool welcome West Ham on Anfield on Saturday with just one place and one point separating the two teams in the Premier League standings.
Newcastle United caretaker manager John Carver is still searching for his first win, and will be hopeful of getting it against Hull City at the KC Stadium on Saturday.
Goals seem guaranteed in Sunday's Premier League clash between Southampton and Swansea at St Mary's Stadium
Olivier Giroud may have been restricted by injury to seven starts for Arsenal in the Premier League this season, but he is now fully fit, back on the goal trail and threatening to add to Aston Villa's problems on Sunday.
Manchester City, five points behind Premier League leaders Chelsea, will be banking on star striker Sergio Aguero to ensure they don't fall further adrift.
Guinea will be hoping their good fortune at the 2015 Africa Cup of Nations continues when they meet Ghana in a quarter-final clash in Malabo on Sunday.
- Flag day at the KC?
- Guinea v Mali
- Mourinho motivated for cup tie
- Chelsea v Liverpool
- Senegal v Algeria
- South Africa v Ghana
- DR Congo v Tunisia
- Cape Verde v Zambia
- Chelsea v Bradford
- Southampton v Crystal Palace
- Cameroon v Guinea
- Tottenham v Leicester
- Birmingham v West Brom
- Blackburn v Swansea
- Brighton v Arsenal
- Sunderland v Fulham
- Man City v Middlesbrough
- De Gea agent coy on rumours
- Liverpool v Bolton
- Cambridge Utd v Man Utd
- Ghana v Algeria
- South Africa v Senegal
- Cape Verde v DR Congo
- Zambia v Tunisia
- Eq Guinea v Burkina Faso