Aston Villa will be looking to put some daylight between themselves and the relegation zone when they host Southampton on Saturday afternoon.
SuperSport United will continue their push to climb up the standings when they welcome Bidvest Wits to the Lucas Moripe Stadium on Saturday afternoon.
Cardiff will look to build on their confidence-boosting win over Southampton when they host Stoke City at the Cardiff City Stadium on Saturday.
Manchester City will be looking to put their midweek blip against Sunderland behind them when they face West Brom on Monday night.
Manchester United manager David Moyes returns to Goodison Park on Sunday looking to avoid yet another unenviable record.
Fulham have it all to play for when they travel to White Hart Lane for their Premier League fixture against Tottenham on Saturday.
Platinum Stars will hand late fitness tests to Henrico Botes and Takesure Chinyama ahead of Saturday's clash against Arrow.
There will be no favours expected when Mpumalanga Black Aces host Polokwane City in the PSL on Sunday afternoon.
Athletic Bilbao have a glorious opportunity to inflict more misery on defending champions Barcelona in their La Liga fixture on Sunday.
Chelsea will have the chance to take over at the top of the standings when they welcome Sunderland to Stamford Bridge on Saturday.
Hull will host Arsenal in a Premier League encounter on Saturday which will double as a dress rehearsal for next month's FA Cup final.