Maritzburg United have their third chance in recent weeks to move off the bottom of the Premiership table when they entertain SuperSport United at Harry Gwala Stadium on Friday.
Holders Sevilla will attempt to put one foot in the Europa League final when they face Shakhtar Donetsk in the first leg of their semi-final tie at Arena Lviv on Thursday night.
Manchester City welcome Real Madrid to the Etihad Stadium on Tuesday in a bid to take another step towards the club's first ever appearance in a Champions League final.
Tottenham manager Mauricio Pochettino is likely to name an unchanged squad for the crunch clash with West Bromwich Albion at White Hart Lane on Monday evening.
Mamelodi Sundowns will look to move one step closer to the Premiership title against Ajax Cape Town at Athlone Stadium on Wednesday.
Chippa United will be looking to cement their place in the top-eight when they host Platinum Stars at the Wolfson Stadium on Wednesday.
Orlando Pirates will be on a high after their Nedbank Cup exploits when they host Polokwane City at the Orlando Stadium on Wednesday evening.
The University of Pretoria will be hoping to take one step closer to Premiership safety on Wednesday evening when they host an out of form Kaizer Chiefs side at the Tuks Stadium.
Wits will need to get over their Nedbank Cup exit and focus on keeping up the pace in the Premiership title when they take on SuperSport United on Tuesday.
Sunderland will hope to repeat last weekend's heroics with an unlikely win against Arsenal on Sunday, while Arsene Wenger needs to appease the Gunners' agitated fans.
Leicester City will be looking to widen the gap between them and second-placed Tottenham when they welcome Swansea City to the King Power Stadium on Sunday.
Crystal Palace and Watford lock horns in the FA Cup semi-finals at Wembley Stadium on Sunday, with both teams seeking only their second appearance in the final.
Southampton will be looking to pile more misery on relegated Aston Villa when they two teams square off at Villa Park on Saturday.
Everton will be banking on Romelu Lukaku to get them through to the FA Cup final at the expense of Manchester United at Wembley Stadium on Saturday evening.
- Mamelodi Sundowns v Orlando Pirates
- Polokwane City v Baroka FC
- Liverpool v Newcastle
- Manchester City v Stoke City
- Free State Stars v Bidvest Wits
- SuperSport United v Black Aces
- Benitez: We are playing with passion
- Manchester United v Crystal Palace
- Mamelodi Sundowns v AS Vita
- Liverpool v Everton
- West Ham United v Watford
- Newcastle United v Manchester City
- Rashford sends Villa to the Championship
- Bournemouth v Liverpool
- Manchester United v Aston Villa
- Arsenal v Crystal Palace
- Kaizer Chiefs v Ajax Cape Town
- Newcastle v Swansea City
- Sundowns v Jomo Cosmos
- Norwich City v Sunderland
- West Brom v Watford
- Stoke City v Tottenham Hotspur
- Everton v Southampton
- Platinum Stars v SuperSport Utd
- Leicester City v West Ham