Everton will attempt to displace Stoke in the top half of the Premier League table when they clash at the Britannia Stadium on Saturday.
Newcastle will attempt to climb out of the relegation zone when they welcome West Brom to St James' Park on Saturday.
Liverpool will be looking to get back to winning ways when they host Sunderland at Anfield in the Premier League on Saturday.
Both sides are in desperate need of a win when Aston Villa host Norwich City at Villa Park in the Premier League on Saturday.
New SuperSport United coach Stuart Baxter will be targeting the first win of his tenure when Ajax Cape Town visit the Lucas Moripe Stadium on Sunday afternoon.
Crystal Palace will be desperate to get their season back on track when they travel to South Wales for a Premier League encounter against Swansea on Saturday.
It's a top-of-the-table clash as Premier League leaders Leicester City visit second-placed Manchester City at the Etihad Stadium on Saturday.
Arsenal will be desperate to rediscover their winning form when they take on Bournemouth at Dean Court on Sunday.
Southampton are looking to keep their good form going when they welcome West Ham United to St Mary's on Saturday.
Table-topping Mamelodi Sundowns face a tough test away to a resilient Free State Stars at the James Motlatsi Stadium on Sunday afternoon.
Chippa United will be hoping to bounce back from consecutive defeats when they take on Jomo Cosmos at the Buffalo City Stadium on Saturday night.
Kaizer Chiefs will hoping to make it six points out of six when they host Premiership basement boys Maritzburg United at FNB Stadium on Saturday.
Kaizer Chiefs ended their two-game winless streak this week and they will hoping to make it six points out of six when they host Premiership basement boys Maritzburg United at FNB Stadium on Saturday.
Second-placed Mpumalanga Black Aces will continue their pursuit of Mamelodi Sundowns at the top of the Premiership table when they welcome Bloemfontein Celtic to the Mbombela Stadium on Saturday.
- Bidvest Wits v Platinum Stars
- Uni of Pretoria v Free State Stars
- Orlando Pirates v Ajax Cape Town
- Watford v Chelsea
- Polokwane City v Maritzburg
- Everton v Newcastle
- West Brom v Swansea City
- Manchester United v Stoke City
- Hiddink admits that Hazard could leave
- Sunderland v Man City
- Leicester City v Liverpool
- West Ham v Aston Villa
- Sundowns v Chippa Utd
- Arsenal v Southampton
- Allen desperate for Premier League action
- Pellegrini: Foxes have the edge
- Golden Arrows v Kaizer Chiefs
- Bloem Celtic v Bidvest Wits
- Portsmouth v Bournemouth
- Crystal Palace v Stoke City
- Platinum Stars v Uni. of Pretoria
- Liverpool v West Ham
- Maritzburg v Sundowns
- Colchester United v Tottenham
- Nottingham Forest v Watford