A place in the MTN8 final awaits as Bidvest Wits host Ajax Cape Town at the Bidvest Stadium on Sunday.
Stoke City and West Brom will be both looking for their first win of the season when they meet at Britannia Stadium on Saturday.
Chelsea will be looking to put their early-season stutter behind them when they welcome Crystal Palace to Stamford Bridge on Saturday.
Aston Villa will be looking to avoid a third straight Premier League defeat when they welcome Sunderland to Villa Park on Saturday afternoon.
Arsenal will be hoping for more consistency when they travel to St James' Park to face Newcastle in the Premier League on Saturday.
Leicester City are enjoying a flying start the Premier League season, and will be in good spirits on their trip south to face top-flight newcomers Bournemouth on Saturday.
Platinum Stars will be looking for their first Premiership win of the season when they entertain Lamontville Golden Arrows in Rustenburg on Wednesday.
Skipper Vincent Kompany believes early Premier League pace-setters Manchester City are benefiting from increased competition for places in the squad.
Wits will be looking to bounce back from their weekend humbling when they come up against Maritzburg United in a Premiership meeting on Wednesday.
Ajax Cape Town will be riding a wave of confidence when they welcome Free State Stars to Athlone Stadium in the Premiership on Wednesday.
Winless Bloemfontein Celtic will be desperate to make it third time lucky when they entertain Orlando Pirates in the Premiership at the Free State Stadium on Wednesday.
Manchester United will be looking to secure their place in the Champions League group stages when they face Club Brugge in the second leg of the play-offs.
Mpumalanga Black Aces and Mamelodi Sundowns have both taken an early lead in the Premiership standings ahead of their clash at Mbombela Stadium on Tuesday.
SuperSport United will be looking to maintain their unbeaten start to the Premiership season when they welcome Jomo Cosmos to the Lucas Moripe Stadium on Wednesday.
- Polokwane City v Kaizer Chiefs
- Capital One Cup R2 preview
- Chippa Utd v Pretoria University
- Arsenal v Liverpool
- Watford v Southampton
- Sakho offered new Liverpool deal
- West Ham v Bournemouth
- Manchester United v Newcastle
- Jomo Cosmos v Golden Arrows
- Crystal Palace v Aston Villa
- West Bromwich Albion v Chelsea
- Mamelodi Sundowns v Wits
- Black Aces v SuperSport United
- Everton v Manchester City
- Pretoria University v Polokwane
- Kaizer Chiefs v Free State Stars
- Bloem Celtic v Platinum Stars
- Orlando Pirates v AC Leopards
- Ajax Cape Town v Maritzburg
- Southampton v FC Midtjylland
- Orlando Pirates v Chippa United
- Liverpool v AFC Bournemouth
- Manchester City v Chelsea
- Crystal Palace v Arsenal
- West Ham v Leicester