Orlando Pirates will be looking to make a strong start under Vladimir Vermezovic as they travel to Moroka Swallows on Wednesday.
Arsenal face arguably their biggest challenge of the season on Tuesday as they look to overturn a 2-0 deficit against Bayern Munich at the Allianz Arena.
Steve Komphela will be hoping Maritzburg United's upward curve continues when he faces former employers Free State Stars on Tuesday.
AmaZulu will be without key striker Bongani Ndulula for their Premiership clash against Mamelodi Sundowns at Princess Magogo Stadium on Sunday.
Hull City will be keen to prevent Sunderland from another cup semi-final when the two sides square up in the FA Cup quarter-finals on Sunday.
Orlando Pirates interim boss Eric Tinkler will be hoping to end his tenure on a high when his team face the University of Pretoria on Saturday.
Chelsea hope to consolidate their position at the top of the Premier League standings when they host Tottenham Hotspur.
Cardiff City hope to return to winning ways when they host Fulham in a Premier League fixture this Saturday.
Manchester United will look to build on their victory last time out when they travel to the Hawthorns to face West Brom on Saturday.
Bidvest Wits will be searching out a fourth consecutive win in the league when they face Polokwane City in the Limpopo this weekend.
Norwich will be hoping to bounce back from a 4-1 defeat to Aston Villa when they welcome Stoke City to Carrow Road on Saturday.