Polokwane City will be out to try and consolidate their top eight position when they host struggling Free State Stars at the Peter Mokaba Stadium on Saturday.
Leicester need some kind of great escape to avoid relegation and will be desperate for three points when Swansea visit the King Power Stadium on Saturday.
Southampton will still retain some fading hopes of European football for next season, and see the visit to the Britannia Stadium as their last chance.
Crystal Palace will be targeting more of the same when they welcome out-of-sorts West Brom to Selhurst Park on Saturday afternoon.
Swallows will continue their quest to avoid the relegation axe when they take on SuperSport United at Peter Mokaba Stadium on Saturday night.
Manchester City will looking to restore some pride when they take on West Ham United at the Etihad Stadium on Sunday afternoon.
Liverpool will be looking to book their place in the FA Cup final when they take on Aston Villa at Wembley Stadium on Saturday.
Bidvest Wits will look to continue putting pressure on the Premiership's top three when they host Chippa United at the Bidvest Stadium on Saturday.
Arsenal will be looking to take another step towards a successful FA Cup title defence when they face Reading at Wembley Stadium in the semi-finals on Saturday evening.
Everton will be looking to keep the momentum going when Premier League strugglers Burnley visit Goodison Park on Saturday.
Tottenham will be desperate to get their Premier League campaign back on track when they travel to St James' Park to face Newcastle on Sunday.
Chelsea will welcome Manchester United to Stamford Bridge on Saturday evening for a potentially season-defining Premier League encounter.
Midfielders Jacky Motshegwa and Gregory Maasdorp are both out of Bloemfontein Celtic's Premiership meeting against Maritzburg United on Sunday.
Ajax Cape Town will be looking to strengthen their top-eight bid when they welcome University of Pretoria to the Cape Town Stadium on Friday evening.
- Wenger expects Walcott stay
- PSG v Barcelona
- FC Porto v Bayern Munich
- Black Aces v Maritzburg Utd
- AmaZulu v Polokwane City
- Rodgers: City opened the door
- Sundowns v Bloem Celtic
- Juventus v Monaco
- BV Wits v Orlando Pirates
- Liverpool v Newcastle
- Tottenham v Aston Villa
- Sunderland v Crystal Palace
- SuperSport United v Arrows
- Black Aces v Sundowns
- West Ham v Stoke City
- West Brom v Leicester
- Southampton v Hull City
- Man United v Man City
- QPR v Chelsea
- Burnley v Arsenal
- Ajax Cape Town v Wits
- Bellerin relishing Debuchy battle
- Kaizer Chiefs v AmaZulu
- Blackburn v Liverpool
- Rodgers: We need solutions