Everton make the long trip to Russia on Thursday to take on FC Krasnodar in a Europa League clash they will be desperate to win.
Liverpool will be hoping to put their domestic troubles behind them when they travel to Basel in the Champions League on Wednesday.
Chelsea will go in search of their first win of the 2014/15 Champions League group stages when they travel to Sporting Lisbon on Tuesday.
Under-fire Newcastle manager Alan Pardew will be desperate to steer his side to their first win of the Premier League season at Stoke on Monday.
Alex Oxlade-Chamberlain fired home in the final 14 minutes to earn Arsenal a 1-1 draw against bitter rivals Tottenham on Saturday.
West Brom will be targeting more of the same when they welcome Premier League newcomers Burnley to the Hawthorns on Sunday.
SuperSport United have an opportunity to steer well clear of the relegation zone when they play against Bloemfontein Celtic on Saturday.
The big news for Ajax CT during the course of the week is that captain Travis Graham will return to the fray for the crucial fixture against Aces.
Sunderland welcome Swansea to the Stadium of Light on Saturday still searching for their first win of the Premier League season.
Pirates will try to build on the momentum they have created when they travel to Port Elizabeth for a Premiership fixture against Chippa.
Moroka Swallows will be looking to get their season back on track when they face Free State Stars at Goble Park on Saturday.
Platinum Stars will be desperate to snap a three-game winless streak when they host University of Pretoria at the Royal Bafokeng Stadium on Sunday.
Crystal Palace and Leicester will lock horns on Saturday, with both sides having enjoyed impressive wins in the Premier League last time out.
Southampton will be looking to maintain their stunning start to the season when they hosts whipping boys QPR at St Mary's on Saturday.
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